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Different physical locations between db and app servers bad idea?

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Say I had 3 app servers (with load balancing in place) in Las Vegas and two MySQL servers in Atlanta; how much does distance affect performance on this sort of situation? Let's assume the db servers are just running master-master so the second one is just there for HA purposes.

My gut feeling tells me this setup vs. a typical LEMP box running WordPress setup will be slower because of the latency but I don't really have a way to test this situation.

Thanks for any advice you guys can give!


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